Raman laser at 1197 nm for photoacoustic imaging of fat Rui Li, *Mikhail N. Slipchenko, Pu Wang, and Ji-Xin Cheng Purdue University, Weldon School of Biomedical Engineering, West Lafayette, Indiana 47907 Abstract. United States Patent 4197009 . However, the fixed 532 nm output is not suitable for spectroscopic PAM. Additionally, it can be used for stimulated Raman imaging in deep tissue, provided that the generated photoacoustic signal is sufficiently strong. A tuning mechanism 14 adjusts the frequency difference between the radiation beams 15, 17 to equal substantially the vibrational … These huge increases in Raman scattering are primarily caused by the increased intensity of the electromagnetic … The coherent anti-Stokes Raman scattering (CARS) and photoacoustic Raman spectroscopy (PARS) spectra of gaseous CHF2Cl and CH3CF2Cl in the 3000 cm-1 region are reported for the first time. However, differentiation of photoacoustic signals is non-trivial hence specificity can be poor. In situ Raman scattering of graphene further confirms that the temperature of graphene under laser pulses rises above the boiling point of water but still remains too low to vaporize graphene and create graphene plasma bubbles. Ultrasound detection provides a simple way to discriminate against laser-induced breakdown and allows for the quantification of the stimulated Raman scattering process where direct optical detection is not available. Multimodality Raman and photoacoustic imaging of surface-enhanced-Raman-scattering-targeted tumor cells Wei Shi, aRobert J. Paproski, a,b Peng Shao, Alexander Forbrich, a John D. Lewis, b and Roger J. Zemp a,* a University of Alberta, Department of Electrical and Computer Engineering, Second Floor ECERF, 9107-116 Street, It is important, since, unlike spontaneous Raman scattering spectroscopy, which provides with the whole vibrational spectrum for a single wavelength excitation, stimulated Raman scattering excitation is limited to a single vibrational line. Many approaches have been … Normal electronic (and vibronic) Raman scattering. Units and orders of magnitude. The Raman scattering amplification associated with this phenomenon is known as surface-enhanced Raman scattering (SERS) spectroscopy . The sensitivity of a new spectroscopic technique, photoacoustic Raman spectroscopy (PARS), has been improved substantially by the use of high-peak-power pulsed lasers. Spectroscopic photoacoustic microscopy in the 1064–1300 nm range using a pulsed multi-color source based on stimulated Raman scattering Abstract: Photoacoustic microscopy (PAM) provides excellent image contrast based on optical absorption. Abstract: A method and apparatus for spectroscopic material anaylsis are provided. A very common pulsed optical source is a frequency-doubled Q-switched Nd:YAG laser. The discovery of the photoacoustic effect dates to 1880 when Alexander Graham Bell showed that thin discs emitted sound when exposed to a beam of sunlight that was rapidly interrupted with a rotating slotted disk. To accomplish this goal, significant optical scattering in tissues has to be overcome while achieving molecular specificity without resorting to extrinsic labeling. Multimodality Photoacoustic and Raman Imaging. low frequency Raman scattering ofCdS 1-xSe x, only the spheroidal modes ofl=0 (symmetrical mode) and forl=2 (quadrupole mode) are observed. We herein report a bandgap engineering strategy to develop an intrinsically Raman-photoacoustic (PA) active probe that is based on semiconducting conjugated polymers. Owing to much weaker acoustic scattering in tissues as compared to optical scattering, photoacoustic detection of harmonic molecular vibration has enabled significant improvement in imaging depth. We demonstrate a simple approach to increase the number of wavelengths by using stimulated Raman scattering (SRS) in an … Lipidrich tissue, such as atherosclerotic plaques and myelinated nerve fibers, exhibits an optical absorption peak near 1210 nm. In this paper a multi-wavelength optical-resolution photoacoustic microscopy (OR-PAM) system using stimulated Raman scattering is demonstrated for both phantom and in vivo imaging. Two coherent beams 15, 17 of monochromatic radiation are directed through a sample of material. The vibrational spectra (Raman, photoacoustic and Fourier transform infrared and inelastic neutron scattering) ... Raman and neutron inelastic scattering (INS), and applied this approach in the case of Mg 2FeH 6/D 6. Photoacoustic imaging is a novel imaging technology for visualizing optically-absorbing structures in vivo with simultaneous high contrast and high spatial resolution. The Raman amplifier has been constructed using 4.5 km of dispersion shifted fiber, a 1651 nm DFB seed laser and a commercial 4W … The generated photoacoustic signal is sufficiently strong address the problem of chemically specific imaging in deep.. Fiber laser is coupled into a single-mode polarization maintaining fiber in tissues has to be overcome achieving. Vivo evaluation of photoacoustic raman scattering on tumor‐bearing xenografts demonstrates its high efficacy in eradication of solid tumors NIR‐II. 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